According to Reuters:
A study of Merck & Co Inc's cervical cancer vaccine Gardasil found that allergic reactions were uncommon and most young women can tolerate subsequent doses.
The clinical recommendation is that females with suspected hypersensitivity to the quadrivalent vaccine should be evaluated before receiving more doses, and any challenges with the same vaccine should be carried out in a supervised setting.
Skin tests of 25 girls with suspected hypersensitivity showed that only three of them experienced probable reactions. The researchers also noted that suspected reactions such as hives are often "idiosyncratic" and do not increase the risk of adverse reactions in subsequent shots.
Over 100 different HPV types have been identified. Types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68 are "high-risk" sexually transmitted HPVs and may lead to the development of cervical intraepithelial neoplasia (CIN), vulvar intraepithelial neoplasia (VIN), penile intraepithelial neoplasia (PIN), and/or anal intraepithelial neoplasia (AIN).
Gardasil is designed to prevent infection with HPV types 16, 18, 6, and 11. HPV types 16 and 18 currently cause about 70% of cervical cancer cases.
Allergic reactions to Gardasil uncommon. Reuters, Dec 2008.
Hypersensitivity reactions to human papillomavirus vaccine in Australian schoolgirls: retrospective cohort study. Liew Woei Kang et al. BMJ 2008;337:a2642
Human papillomavirus from Wikipedia, the free encyclopedia.
Gardasil from Wikipedia, the free encyclopedia.
Image source: HPV types and associated diseases, Wikipedia, public domain.