Histamine is an important chemical mediator of allergic rhinitis (AR).
Histamine structure. Image source: Wikipedia.
Histamine H3 receptors (H3R) is localized around submucosal glands. H3R plays an important role in the secretion of submucosal glands in the nose.
The seminal work on histamine was published in 1910, but histamine was not identified as a mediator of anaphylactic reactions until 1932. Histamine is a major mediator responsible for the symptoms of allergic rhinitis, with its activities mediated through 4 G protein-coupled receptors. Most of histamine's effects are exerted through the H₁ receptor, but some effects are through the H₂ and H₃ receptors, and possibly also through the H₄ receptor.
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H(3) receptor antagonist is a new therapeutic strategy for allergic rhinitis, trials are ongoing. JACI, 2012.