Differences between commercial IVIG preparations: Gammagard and Octagam

Gammagard Liquid is the first 10% IVIG solution with no added carbohydrates or sodium. Baxter is replacing Gammagard S/D with Gammagard Liquid.

Sodium concentration

Gammagard: No added sodium. When reconstituted with the total volume of diluent (Sterile Water for Injection, USP) supplied to 5%, Gammagard contains a physiological concentration of sodium chloride (approximately 8.5 mg/mL) and has a pH of 6.8 ± 0.4.

Octagam: sodium content of the final solution is ≤ 30 mmol/l and the pH is between 5.1 and 6.0.


Gammagard osmolality is 240-300 mOsmol/kg, similar to physiological osmolality (285 to 295 mOsmol/kg).

Octagam osmolality is 310 - 380 mosmol/kg.


Gammagard Liquid, Baxter, $129.60/gm

Octagam, Octapharma, $118.34/gm

Prices represent cost per unit specified and are representative of "Average Wholesale Price" (AWP).

Since 1990s, no transmission of infectious diseases have been reported from U.S.-licensed IVIG products.

Intravenous immune globulin. Hopkins HIV Guide.
Octagam, Octapharma.
Gammagard Liquid, Baxter.
Image source: Wikipedia.


  1. Actually, what are differences between Gammagard and Octagam? What are they used for? If I am interested in finding it after knowing information about it, where could I get it? Thanks.

  2. I have always a desire to discovering information about IVIG preparations. Anyway,

    I think you missed some points. On the beginning of the paragraph, it can be perceived that the Gammagard is not contained sodium, meanwhile the Octagam is consisted of sodium (since it is the result of the mixture).

    Looking forward for some enlightenments.