Long-term treatment with aspirin desensitization: 300 mg aspirin daily is the optimal dose

What is the triad of aspirin-exacerbated respiratory disease (AERD)?
Samter's triad include asthma, aspirin sensitivity, and nasal/ethmoidal polyposis.

ASPirin:

Asthma
Sensitivity to aspirin
Polyps

The daily dose of aspirin in desensitization in aspirin-sensitive asthmatics with nasal polyps is still a matter of debate.

This study compared 2 doses of aspirin during the first year of desensitization: either 100 or 300 mg aspirin daily.

The authors concluded that aspirin desensitization followed by 300 mg aspirin daily was efficacious and resulted in polyp-free nasal airways. Aspirin in a dose of 100 mg daily was not sufficient to reduce nasal and bronchial or pulmonary symptoms and to prevent recurrent nasal polyps.


Management of adverse drug reactions: APD or PAD. See more Mind Maps of Drug Hypersensitivity here.

References:
Long-term treatment with aspirin desensitization: a prospective clinical trial comparing 100 and 300 mg aspirin daily. A. Rozsasi, D. Polzehl, T. Deutschle, E. Smith, K. Wiesmiller, H. Riechelmann, T. Keck. Allergy, Volume 63 Issue 9, Pages 1228 - 1234, 2008.
Sinusitis: A Short Review
Mnemonics: Drug Hypersensitivity
Mind Maps: Drug Hypersensitivity