Angioedema: a 24-hour photo diary by a patient posted on Flickr
Angioedema: a 24-hour photo diary by a patient posted on Flickr
The patient took pictures of herself and uploaded them to the photo sharing website Flickr under a Creative Commons license. She had the impression her symptoms were due to urticaria but since the process affects the subcutaneous tissues (note the upper lip edema), the more likely diagnosis is angioedema and urticaria.
Dr Heinrich Quincke first described the clinical picture of angioedema in 1882, hence the eponym Quincke's edema. Sir William Osler remarked in 1888 that some cases may have a hereditary basis; he coined the term hereditary angio-neurotic edema.
C1 protein, showing subunits C1r, C1s, and the C1q tails. Image source: Wikipedia. Patients with acquired angioedema have low C1q levels AND low C4/C2 levels. In contrast, in hereditary angioedema (HAE) the C1q level is normal.
Classical and alternative complement pathways. Image source: Wikipedia.
Read more about Angioedema at AllergyCases.org.
Update 8/12/2008:
Reuters features our post Angioedema: a 24-hour photo diary by a patient posted on Flickr.
2 comments:
This is a great visual of Hereditary AngioEdema (HAE) and the toll it takes on the patient.
The explanation of the disease is a bit simplistic, however. HAE has 2 types - one with a normal level of C1 that just isn't functioning and one with a low level of C1.
PLEASE see www.haea.org for complete information and help with this disease.
Re: "explanation of the disease is a bit simplistic": This is not HAE. This is acquired angioedema with urticaria due to drug reaction -- a different diseases from HAE.
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