Interview with John Routes: Newborn Screening for “Bubble Boy Disease”

Berci Mesko of ScienceRoll.com interviewed John Routes from the Children’s Hospital of Wisconsin about the screening for Severe Combined Immune Deficiency (SCID), sometimes called “Bubble Boy Disease.”

SCID is a heterogeneous group of genetic disorders characterized by an arrest in T lymphocyte development which leads to an abnormal differentiation of B and NK cells.

References:

Severe combined immunodeficiency: A cohort of 40 patients in Iran. Mehdi Yeganeh et al. Pediatric Allergy and Immunology (OnlineEarly Articles). doi:10.1111/j.1399-3038.2007.00647.x

The state of Wisconsin approach to newborn screening for SCID: 5 infants with SCID detected in 3 years. JACI, 2012.