JACI, Volume 119, Issue 5, Pages 1282-1286 (May 2007)
Eosinophils have a well-established role in the pathophysiology of asthma. The precise role of neutrophils in the pathogenesis of asthma however is unclear. Increased number of neutrophils are present in the airways during the late-phase reaction after allergen challenge, in fatal or nocturnal asthma, and in severe asthma.
"Further studies examining the mechanisms by which neutrophils may lead to airway remodeling are required as well as studies investigating the potential beneficial effects of antineutrophil therapies in severe asthma."
In patients with asthma and chronic productive cough, polymorphonuclear (PMN) neutrophil leukocytes in sputum suggest:
(C) presence of a foreign body
(D) exercise-induced asthma
(E) extrinsic asthma
Correct answers: A, B, C
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